Enter the values. Tab across each row. Review a provisional interpretation, save or download, and start the next case.
No PHI: Do not enter or upload patient names, MRNs, dates of birth, accession numbers, or other identifying information. Use a non-identifying case label and username.
This tool is under development and is not intended for clinical use or patient-care decisions.
Choose a synthetic patient to load the numerical fields. Review the observations, then click “Review & provisional interpretation,” just as you would for a manually entered case. Demos are never saved to the case corpus or counted as clinical validation.
Edits remain synthetic. Start a new entry to enter your own case.
Manual entry and screenshot extraction run in this tab. “Save structured case” sends only confirmed values and results to bounded site storage, not Drive. Screenshots are never sent to the server. Save or download before closing.
Controls and separately incubated 1:1 values are optional. Leave unavailable values blank (or use NP, U, or INV). NPP, the patient, and the relevant mix must be available at the same time for a percent-correction calculation; missing data are never treated as zero. Separate-incubation fields are at 60 and 120 minutes.
Storage uses a daily salted network tag to limit abuse; raw IP addresses and screenshots are not stored. Limits are 20 cases per network per day, 200 overall per day, and 5,000 total. Download remains available if a limit is reached.
Mixing studies remain useful, but their clinical value and interpretation are debated. Results depend on the question being asked, reagent, mixture, incubation, and definition of correction. No single method reliably separates every deficiency from every inhibitor; medication effects and clinical context matter.
Chang, Tillema, and Scherr’s 2002 study evaluated percent correction in 1:1 and patient-heavy 4:1 mixtures, including incubation. This tool implements a local Chang-based adaptation, not a universal standard. Its versioned aPTT rules combine the 1:1 result with the 4:1 pathway and preserve equivocal patterns.
The 2024 International Council for Standardization in Haematology recommendations favor 1:1 mixing, locally validated cutoffs, and an algorithm combining correction indices, subtraction, and incubation when indicated. Here, that approach is a development comparator only; it never changes the local Chang-based headline.
A correcting or noncorrecting pattern guides further investigation. It does not establish a particular factor deficiency or diagnose lupus anticoagulant.
Percent correction: how much of the patient’s prolongation toward normal pooled plasma (NPP) disappears after mixing. Higher means more correction. It is not a factor activity or a probability of disease.
Rosner index: residual prolongation of the 1:1 mix above NPP, scaled to the patient’s clotting time. Lower means more correction. This demo’s local three-zone convention differs from the ICSH suggested correction threshold of ≤15; both require local validation.
The result cards show the exact local aPTT cutoffs. Incubated calculations use patient, mix, and NPP from the same time point. Missing inputs leave the affected calculation unavailable.
Blank cells stay missing. Use NP for not performed, U for unmeasurable, or INV for invalid. Paste changes only the selected study.
This tool is under development and is not intended for clinical use or patient-care decisions.
0 reviewed cases in this tab. Save cases to site storage or download JSON. Export a batch for spreadsheet import or reload a JSON file to continue in another session.
